Item Type | Name |
Academic Article
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Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells.
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Academic Article
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Upstream regions of the c-jun promoter regulate phorbol ester-induced transcription in U937 leukemic cells.
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Academic Article
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Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase.
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Academic Article
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Regulation of myeloid cell growth by distinct effectors of Ras.
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Academic Article
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Bax-induced apoptotic cell death.
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Academic Article
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Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit mediate activation of Jak/Stat signaling and differentiation.
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Academic Article
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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway.
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Academic Article
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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.
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Academic Article
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Overexpression of the oncogenic kinase Pim-1 leads to genomic instability.
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Academic Article
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Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor.
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Academic Article
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Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.
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Academic Article
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Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation.
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Academic Article
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The role of the Smad3 protein in phorbol ester-induced promoter expression.
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Academic Article
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The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.
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Academic Article
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Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.
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Academic Article
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Combination of gemcitabine antagonizes antitumor activity of paclitaxel through prevention of mitotic arrest and apoptosis.
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Academic Article
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Induction of the proto-oncogene c-jun by angiotensin II.
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Academic Article
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Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.
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Academic Article
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Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.
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Academic Article
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Cell cycle dependent antagonistic interactions between paclitaxel and carboplatin in combination therapy.
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Academic Article
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Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells.
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Academic Article
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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.
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Academic Article
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells.
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Academic Article
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The Pim protein kinases regulate energy metabolism and cell growth.
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Academic Article
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Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.
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Academic Article
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Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer.
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Academic Article
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Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.
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Academic Article
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Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.
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Academic Article
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Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.
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Academic Article
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Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.
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Academic Article
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The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells.
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Academic Article
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Signal transduction by a CD16/CD7/Jak2 fusion protein.
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Academic Article
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Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.
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Academic Article
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Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2.
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Academic Article
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Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.
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Academic Article
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A critical role for the cytoplasmic domain of the granulocyte-macrophage colony-stimulating factor alpha receptor in mediating cell growth.
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Academic Article
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Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells.
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Academic Article
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Phosphorylation of transcription factors.
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Academic Article
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Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation.
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Academic Article
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The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells.
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Academic Article
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RAS, MYC, and sensitivity to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.
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Academic Article
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The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.
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Academic Article
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Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.
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Academic Article
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Pim family kinases enhance tumor growth of prostate cancer cells.
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Academic Article
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ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.
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Academic Article
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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
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Academic Article
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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
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Academic Article
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p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.
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Academic Article
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Regulation of Skp2 levels by the Pim-1 protein kinase.
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Academic Article
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The BH3 mimetic ABT-737 induces cancer cell senescence.
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Academic Article
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Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60).
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Academic Article
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Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor.
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Academic Article
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The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.
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Academic Article
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In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.
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Academic Article
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Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.
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Academic Article
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A peptide encoding the c-Jun delta domain inhibits the activity of a c-jun amino-terminal protein kinase.
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Academic Article
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Multiple signal transduction pathways mediate c-Jun protein phosphorylation.
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Academic Article
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Regulation of jun/AP-1 oncoproteins by protein phosphorylation.
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Academic Article
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The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells.
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Academic Article
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Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.
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Academic Article
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Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
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Academic Article
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The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation.
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Concept
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Proto-Oncogene Proteins c-pim-1
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Concept
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Cyclin-Dependent Kinase Inhibitor p21
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Concept
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Proto-Oncogene Proteins c-bcl-2
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Concept
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Proto-Oncogene Proteins c-mdm2
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Concept
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Proto-Oncogene Proteins c-met
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Concept
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Genes, ras
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Concept
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Proto-Oncogene Proteins c-akt
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Concept
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Proto-Oncogene Proteins c-myc
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Concept
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Proto-Oncogene Proteins c-jun
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Concept
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Proto-Oncogene Proteins p21(ras)
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Concept
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Proto-Oncogene Proteins c-fos
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Concept
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Proto-Oncogene Proteins
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Academic Article
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Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.
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Academic Article
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The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
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Academic Article
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Induction of differentiation and c-jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases.
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Academic Article
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Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.
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Academic Article
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The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.
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Academic Article
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Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors.
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Academic Article
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Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.
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Academic Article
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases.
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Academic Article
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Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset.
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Academic Article
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PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
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Academic Article
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Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
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Academic Article
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PIM kinase (and Akt) biology and signaling in tumors.
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Academic Article
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PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.
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Academic Article
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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.
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Academic Article
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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase.
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Academic Article
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Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
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Academic Article
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PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth.
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Academic Article
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PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
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